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Measurement of 25OH Vitamin D

Since many years the role of vitamin D in bone and mineral metabolism was recognized in bone-related diseases. Clinical applications of 25OH Vitamin D measurements were merely related to the diagnosis and monitoring of therapy for rickets (children), osteomalacia, postmenopausal osteoporosis, and renal osteodystrophy. As a results of more recent studies a link between Vitamin D deficiency and many other diseases is suggested. These include cancer, cardiovascular disease, autoimmune diseases, diabetes, depression and many others.


The measurement of the 25OH Vitamin D concentration in serum or plasma is so far the best indicator of Vitamin D nutritional status. It is generally accepted that serum 25OH Vitamin D levels reflect the body’s storage levels of Vitamin D and correlate with the clinical symptoms of Vitamin D deficiency. There is no consensus about the optimal 25OH Vitamin D level, but many publications suggest a range ≥30 ng/mL (>80nmol/L) as optimal.


  • Diagnosing Vitamin D insufficiency or deficiency, to help identifying individuals who may benefit from Vitamin D supplementation to reach optimal levels.
  • Monitoring response to Vitamin D supplements for bone-related diseases e.g. rickets (children), osteomalacia, postmenopausal osteoporosis, and renal osteodystrophy or non-bone related diseases.
  • Diagnosing Vitamin D toxicity, e.g. patients with suspected toxicity (hypercalcemia).

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